Ангедония, и в частности социальная ангедония – важный психопатологический симптом, играющий ключевую роль в развитии депрессий и шизофрении. У здоровых людей уровень социальной ангедонии ассоциирован с изменением структуры, активации и функциональных связей различных участков префронтальной коры, височной и височно-теменной областей, а также базальных ядер. Для пациентов с шизофренией ключевые фМРТ-корреляты социальной ангедонии локализуются в височной доле. В отношении лиц с депрессией и другими психическими расстройствами полученные результаты недостаточны для обобщения. В отличие от физической ангедонии, социальная не демонстрирует специфичной ассоциации с объемом и активацией прилежащего ядра.
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Идентификаторы и классификаторы
- SCI
- Биология
У молодых людей с высоким уровнем социальной ангедонии усилены функциональные связи ретроспленальной коры с правой веретенообразной извилиной [140], ретроспленальной коры с корой островка в обоих полушариях и со средней лобной извилиной и парагиппокампальной области со средней лобной извилиной [145], прилежащего ядра со средней лобной извилиной, вентрального хвостатого ядра с островковой корой и передней дорсальной скорлупы с верхней лобной извилиной [131] в состоянии покоя. Однако у них слабее функциональные связи гиппокампа с парагиппокампальной корой [145] и прилежащего ядра с задней поясной извилиной [131]. У здоровых людей с социальной ангедонией сеть социальных функций более дифференцирована; усилены ассоциации веретенообразных извилин, миндалин, левого предклинья, правой нижней орбитофронтальной коры и отдельных областей мозжечка [148].
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