The Russian economic space is characterised by a significant differentiation in the levels of socioeconomic development of the country’s various regions, which manifests itself in natural, territorial, socio-cultural, economic, political and other aspects. The results of socio-economic differentiation are unique regional socio-economic systems, which necessitates the formation of individual approaches to managing their development. Therefore, management decisions made at the federal centre, as well as by regional authorities, affect the activities of economic entities in the regions and the population’s level of well-being in different ways. Social security is an integral element of the high quality of life of the population and is largely the basis for improving the economic status of the region, increasing the value of human capital. Thus, it is necessary to develop methods and tools for ensuring the social safe development of regional socio-economic systems, considering the specific characteristics of each region. From these perspectives, we can discuss the stability and social performance of the regional economy. Despite a broad scientific background, the factors contributing to the development and the results of regional socio-economic systems, considering the need for social security, have not been examined. The present research aims to fill this gap by developing a management model for the social and safe development of Russia’s regions, using the city of St Petersburg as the case study