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The article is devoted to the national and international vectors of constitutional reform in the Republic of Uzbekistan. The author considers the main amendments, additions and clarifications of articles and norms in the new version of the Constitution of the Republic of Uzbekistan, adopted for the purpose of further development of Uzbekistan as a sovereign, democratic, legal, social and secular state, based on the constitutional principle of ensuring a system of checks and balances between the branches of power, as well as on universally recognized principles and norms of international law. The article notes that based on the proposals of the citizens of the republic during the national discussion, the provisions on human and citizen’s rights and freedoms have tripled in the updated Constitution of the Republic of Uzbekistan. At the same time, the principle ‘For the sake of human dignity’ has been recognized as the main criterion in the Constitution, laws and the activities of State bodies.